Neuroendocrine Tumor(NET)

Neuroendocrine Tumor Care & Treatment in Delhi

Dr. Neeraj Goel

Medically Reviewed By: Dr. Neeraj Goel, MBBS, MS, MCh (GI Surgery)

Designation: Director – GI Oncology, GI & HPB Surgery

Clinical Review Date: August 22, 2026

What is a Neuroendocrine Tumor (NET)?

Neuroendocrine tumors—or NETs—are an uncommon type of tumor that starts inside neuroendocrine cells scattered across your body. These cells are like a cross between nerve cells and hormone-producing cells.

Most people who get them have tumors that grow very slowly, and they can sit quietly for years before anyone spots them. Most folks only find them by accident during a routine ultrasound or scan for something else. But some can turn aggressive and spread into nearby lymph nodes or the liver. Modern treatments bring together targeted pills, radioactive therapies, precise surgery, and liver procedures to get rid of the tumor while making sure your digestion and body keep working properly.

What Do Neuroendocrine Cells Actually Do?

These cells help manage daily jobs all over your gut and organs:

  • Make hormones to break down food and control stomach acid.
  • Signal your bowels so food moves through your gut without trouble.
  • Help your pancreas keep your blood sugar steady.
  • Control blood flow and fluid levels across your body.

You need these systems to run smoothly to feel well. Because these cells make hormones, a tumor can either dump extra hormones into your blood and cause odd flare-ups, or simply sit quiet and slowly get bigger.

Common Causes and Risk Factors Most cases do not have a single known cause, but certain family traits can raise the risk:

  • Functional Tumors: Growths that make extra hormones, including insulinomas, gastrinomas, VIPomas, and glucagonomas.
  • Non-Functional Tumors: Growths that do not make hormones, which means you often do not feel them until they push against other organs.
  • MEN-1 Syndrome: A known genetic condition passed down in families that raises the risk of endocrine tumors.
  • Other Genetic Conditions: Inherited conditions like Von Hippel-Lindau disease, Neurofibromatosis Type 1, and Tuberous Sclerosis.
  • Common organs involved: The small bowel, appendix, stomach, rectum, and pancreas.

Having a risk factor does not mean you will definitely get a tumor, but it is a good reason to get checked if something feels off.

Symptoms to Look Out For. At first, you might not feel a thing. What you feel later depends on where the lump is and whether it makes hormones:

  • Early Warning Signs: A dull ache in your belly, dropping weight without trying, constant tiredness, not feeling hungry, bloating, and changes in your bowel habits.
  • Hormone Warning Signs: Shakiness, sweating, and dizziness from sudden low blood sugar, bad stomach ulcers that keep coming back, watery diarrhea that leaves you dehydrated, or bright red face flushing and rashes.
  • Later Warning Signs: Yellow tint in your eyes or skin (jaundice), a swollen belly filled with fluid, an enlarged liver, or a blocked bowel.

Diagnostic Tests

  • Ga-68 DOTATATE PET-CT Scan: The gold-standard scan that identifies neuroendocrine cells, detects even tiny tumors, and shows distant spread.
  • Triple-Phase CT & MRI: It defines the tumor extent and gives valuable information about the blood vessels.
  • Chromogranin A & Hormone Tests: Blood tests that check general tumor markers and measure specific hormone spikes.
  • Endoscopic Ultrasound (EUS): An endoscope with a small ultrasound probe is placed next to the pancreas to identify tumors and take samples(biopsy).
  • Biopsy: Takes a small sample to check cell grade—Grade 1 (slow-growing), Grade 2 (medium), or Grade 3 (fast-growing).

Stages and Tumor Grading

  • Localized (Grade 1 & 2): Tumors are limited to the organ of origin only.
  • Regional Stage: Tumors have grown out of the organ and involve Lymph nodes.
  • Advanced (Metastatic) Stage: Cancer has reached to distant organs like liver, lung etc.

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Surgery

Resection and Organ-Sparing Removal If the tumor has not spread too far, cutting it out gives you the cleanest shot at getting rid of it for good:

  • Enucleation: Removing the tumor only and preserving the rest of organ so that it keeps functioning normally.
  • Distal Pancreatectomy: Removing the body and tail of the pancreas along with the tumor.
  • Whipple Procedure: A major surgery used for tumors in the head of the pancreas.
  • Bowel Resection: Involved part of the gut is removed with clear margins.

Keyhole and Robotic Surgery

  • Laparoscopic Surgery: Operating through tiny keyhole cuts to cut down on pain and blood loss.
  • Robotic Surgery: Gives the surgeon a high-definition 3D view and wristed tools that move with rock-solid control around delicate blood vessels.

Liver Metastases Care: Because NETs commonly travel to the liver, we use direct liver treatments to keep things under control:

  • Liver Resection: Cutting out tumors that have settled in the liver.
  • Heat Ablation (RFA & Microwave): Using a needle probe to heat up and wipe out small liver tumors right where they sit.
  • Hepatic Embolization: Blocking blood supply to the liver tumors when surgery is not a safe choice.

Targeted Medications & PRRT When surgery is not on the table or tumors have spread, medical therapies step in to keep things in check:

  • Somatostatin Analogues (Octreotide / Lanreotide): Regular injections that stop hormone surges and slow down tumor growth.
  • Targeted Daily Pills: Drugs like Everolimus and Sunitinib that turn off the signals the tumor needs to build new cells.
  • Peptide Receptor Radionuclide Therapy (PRRT): Treatments like Lu-177 DOTATATE that send radiation straight inside tumor cells while protecting healthy tissue.

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Why Consult Dr. Neeraj Goel?

With over two decades experience, our focus has always been on the intricate work of complex pancreatic NETs, bowel surgeries, and liver resections. We combine that hands-on surgical experience with robotic and keyhole tools, allowing us to remove tumors cleanly through tiny, gentle cuts rather than large incisions. You also get far more than just a surgeon in your corner—you have a full team of medical oncologists, nuclear medicine doctors, endocrinologists, and radiologists working closely together to build a personalized care plan tailored to your exact situation.

Clinical Perspective

Treating a neuroendocrine tumor is all about finding the right balance: getting rid of the tumor completely while making sure you keep good digestive and metabolic health. Because many of these tumors grow slowly, taking out the main lump and clearing liver spots gives patients strong long-term survival and a normal daily life. Using keyhole and robotic tools lets us clear the growth cleanly through small cuts, so most patients are up walking the very next day and ready to head home quickly.

Frequently Asked Questions About Neuroendocrine Tumors (NET)

Can neuroendocrine tumors be cured?

Yes. When we catch them early and take them out cleanly with surgery, localized NETs have very high cure rates.

Is a pancreatic NET the same thing as regular pancreatic cancer?

No. Pancreatic NETs start in hormone-making cells and usually grow much slower than typical pancreatic ductal cancer, so they have different treatments and much better outlooks.

What makes a Ga-68 DOTATATE PET scan so helpful?

This tracer molecule is taken up straight by neuroendocrine cells, which light up on PET scan. These tumors can sometimes be missed by CTor MRI.

How does PRRT work?

PRRT connects a tumor-seeking molecule to a small dose of radiation, taking it directly inside the cancer cells to destroy them from within while sparing healthy organs.

What does a high Chromogranin A blood test mean?

Chromogranin A is a protein made by neuroendocrine cells. A higher number can flag an active tumor and helps us track how well your treatment is working over time.

Schedule an Advanced GI Laparoscopic Consultation with Dr. Neeraj Goel

  • Specialist: Neeraj Goel, MBBS, MS, MCh (Surgical Gastroenterology)
  • Designation: Director & Senior Consultant – GI Oncology, GI & HPB Surgery
  • Hospital Address: Dharamshila Narayana Superspeciality Hospital, Vasundhara Enclave, Delhi.
    For Appointment Call: 095992 94453
    Consultation Hours: Monday to Saturday, 10:00 AM to 4:00 PM
  • Clinic Address: DIGS, Room No. 1, UG Floor, C-61A, Rajan Babu Rd, Block C, Adarsh Nagar, Delhi, 110033.
    For Appointment Call: 098113 92062
    Consultation Hours: Monday to Saturday, 06:00 AM to 7:30 PM
  • Clinical Focus: Advanced Laparoscopic & Robotic GI Cancer Resection, Laparoscopic Cholecystectomy, Hernia & Bariatric Surgery
  • Inquiries & Appointments: Dedicated Gastrointestinal & Minimally Access Surgery Outpatient Clinic, Dharamshila Narayana Superspeciality Hospital, Delhi
Medical Disclaimer: This guide is written to give you clear, practical information about neuroendocrine tumors, but it cannot replace sitting down for a one-on-one exam with a specialist. Many neuroendocrine tumors develop quietly over years without obvious symptoms. If you experience persistent abdominal pain, unexplained weight changes, chronic flushing, severe diarrhea, or sudden shifts in blood sugar, get checked promptly by a GI oncology specialist.
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